Converting the substrate specificity of human β- hexosaminidase B, and, new high-performance enzymes confer protease resistance

Has a wild-type human β- hexosaminidase α- subunit derived activity and has resistance to protease, providing a modified β subunit of human β- hexosaminidase. Substitution in the amino acid sequence of β- subunit of the wild-type human β- hexosaminidase, # 312 th to 318 th amino acids in order, respectively, glycine, serine, glutamic acid, proline, serine, glycine, and threonine It has been that comprises the amino acid sequence, the protein.