Effect of different oxygen therapy on blood gas in rats following acute carbon monoxide poisoning

2010 
Objective To observe the effect of different oxygen therapies on blood gas in rats following acute carbon monoxide poisoning. Methods Seventy male Wistar rats were randomly divided into the control group (n=10), the COST group (sacrificed instantly after CO exposure) (n = 12), and the remaining 48 animals were further divided into 4 groups of 12 animals each, i.e. the air breathing group; the nasal catheter oxygen breathing group, the face mask oxygen breathing group, and the hyperbaric oxygen exposure group. The last 4 groups were exposed to either normal air or oxygen for a duration of 100 minutes, following acute carbon monoxide poisoning. The animal model of acute carbon monoxide poisoning (ACOP) was developed as designed, and 3 different therapies were administered to the animals. Then, blood samples were taken from abdominal aorta for blood gas analysis. Results pH: pH value in the COST group was significantly lower than the control group (P 0.05); PaO2 and PaCO2: no statistical significance in PaO2 or PaCO2 could be seen between the groups after ACOP(P >0.05); Lactic acid and COHb%: levels of lactic acid and COHb% in the COST group increased significantly, when compared with those of the control group (P 0.05); Bicarbonate (HCO3 -):statistical differences in HCO3 - between the groups could be noted after ACOP (P < 0. 05). Conclusions Various types of oxygen therapy could rectify hypoxia and metabolic acidosis in rats following ACOP. Compared with other two types of therapy, HBO could remove carboxyhemoglobin (COHb) from the body most significantly. Key words: Oxygen therapy; Acute carbon monoxide poisoning; Rat; Blood gas analysis
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