Avoiding an overdiagnosis of pancreatic pseudocysts.

Background/Aims: Thirty-six cases of pancreatic pseudocysts were retrospectively analyzed, to evaluate the clinical features of the pseudocysts which could not be differentiated from the neuplastic cysts until laparotomy. Methodology: Thirty-one out of 36 cases were diag nosed correctly to be a pseudocyst, in which 10 cases (32.3%) were treated by surgery. Five out of 36 cases were diagnosed to be neoplastic pancreatic cysts (mucinous cystadenoms or cystadenocarcinoma in 4 cases, serous cystadenoma in 1) in which all cases were treated by surgery (100%). To determine the clinical factors contributing to a correct or false diagnosis of pseudocysts, 14 clinical objects were catagorized into several factors and analysed using a contingency table. Results: The clinical factors, including a history of pancreatitis (P=0.070), upper abdominal pain (P=0.083), an age of less than 42 years (P=0.070), and an elevated serum amylase level on admission (≥200 IU/L, P=0.067) were all thought to be helpful in establishing a correct diagnosis of pancrestic peeudocyst. In the morphological studies of computed tomography and ultrasonography, multicystic lesions (P=0.045) and nodular or irregular thickening of the cyst wall (P=0.006) significantly mialead us into making a diagnosis of a neoplastic cyst. Conclusions: In conclusion, the morphological fentures of a multicystic pattern, with either nodular or irregular thickening of the cyst wall, also belong to the common features of the pancreatic pseudocysts Since these features tended to be diagnosed as neoplastic, other clinical factors should thus be referred to, in a comprehensive manner, to establish a correct diagnosis of pancreatic pseudocyst.