Site-specific and Quantitative N-glycan Heterogeneity Analysis of the Charge Isomers of an Anti-VEGF Recombinant Fusion Protein by High-resolution 2-dimensional Gel Electrophoresis and Mass Spectrometry

Xiaoyu Li,Qing He,Zixiang Yu,Yuping Xie,Xinyuan Zhao,Yi Huang,Yongzhong Wang,Xiao Ke,Xiaohong Qian,Jun-Xing Dong,Wantao Ying

Site-specific and Quantitative N-glycan Heterogeneity Analysis of the Charge Isomers of an Anti-VEGF Recombinant Fusion Protein by High-resolution 2-dimensional Gel Electrophoresis and Mass Spectrometry

2020

Xiaoyu Li
Qing He
Zixiang Yu
Yuping Xie
Xinyuan Zhao
Yi Huang
Yongzhong Wang
Xiao Ke
Xiaohong Qian
Jun-Xing Dong
Wantao Ying

Glycan modification prompts important concerns about the quality control of biopharmaceutical production. Conbercept is a multi-glycosylated recombinant fusion protein drug approved for the treatme...

Keywords:

Mass spectrometry
Glycan
VEGF receptors
2 Dimensional Gel Electrophoresis
Fusion protein
Chemistry
Chromatography
Biopharmaceutical
Recombinant DNA
Conbercept
high resolution
Two-dimensional gel electrophoresis
anti vegf

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