Alcalose iatrogênica em cabras após infusão intravenosa de solução eletrolítica contendo 84mEq/L de lactato

EnglishThis study investigated the alkalinizing potential of an intravenous polyionic solution containing 84 mEq/L of lactate on hydroelectrolyte and acid-base balances in healthy goats.Four solutions, containing 28 and 84 mEq/L of lactate (L28 and L84) or bicarbonate (B28 and B84), were formulated. Six healthy Saanen goats were used. All four solutions were infused intravenously in each animal, one at a time, with an interval of 4–5 days between the infusions, at a speed of 33.3 mL/kg/h and totaling a volume equivalent to 10% of their body weight, in 3 h of continuous administration. Samples of venous blood and urine were collected at 0h (start of the infusion), 1.5h (middle of the infusion), 3h (end of the infusion), and 4.5h, 6h, and 24 h from the start of the infusion. The laboratory tests includeddetermination of blood pH, pCO2,HCO3-, base excess (BE), Na+, K+, Cl-, total plasmatic protein, L-lactate, and creatinine. In urine samples, pH, Na+, K+, Cl- , L-lactate,and creatinine were measured. The L28 solution, equivalent to lactated Ringer’s solution, caused a slight increase in the alkaline reserve and did not change the electrolyte balance. The L84 solution resulted in a greater increase in the alkaline reserve, equivalent to the B84 solution, with return to baseline values within 24 h from the start of the infusion.The L84 solution proved to be safe and produced iatrogenic alkalization when infused into healthy goats, without causing side effects portuguesO objetivo deste trabalho foi investigar o potencial alcalinizante de uma solucao poli-ionica intravenosa contendo 84mEq/L de lactato no equilibrio hidroeletrolitico e acido base de cabras saudaveis. Quatro solucoes contendo 28 e 84 mEq/L de lactato (L28 e L84) ou bicarbonato (B28 e B84) foram formuladas. Seis cabras, adultas, da raca Saanen, saudaveis receberam as quatro solucoes por via intravenosa, uma de cada vez, com intervalo de quatro a cinco dias entre as infusoes, a velocidade de 33,3 ml/kg/h, totalizando um volume equivalente a 10% do seu peso corporal, em tres horas de administracao continua. Foram coletadas amostras de sangue venoso e urina antes do inicio da infusao (0h), na metade (1,5h), no fim (3h) e as 4,5h, 6h e 24h apos o inicio da infusao. Os exames laboratoriais consistiram na determinacao do pH sanguineo, pCO2, HCO3-, BE, Na+, K+, Cl-, proteina plasmatica total, lactato L e creatinina. Nas amostras de urina forammedidos o pH, Na+, K+, Cl-, lactato L e creatinina. A solucao L28, equivalente a solucao de Ringer com lactato, causou um aumento leve na reserva alcalina e nao alterou o equilibrio eletrolitico. A solucao L84 resultou em maior aumento da reserva alcalina, equivalente a solucao B84, com retorno dos parâmetros avaliados aos valores basais em ate 24 horas apos o inicio da infusao. A solucao L84 provou-se segura e produziu alcalose iatrogencia em cabras sadias, sem causar qualquer efeito colateral.