Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons

We reported herein an efficient method for constructing dendritic bisphosphonic acid tweezers of generation 1 and 2, which have been proven as versatile surface coatings for metal oxides implants or nanoparticles. These dendritic structures were successully utilized for different purposes: i) biocompatible coverings for iron oxide nanoparticles through in vitro assays, ii) antifouling surface coatings for silica through Quartz Crystal Microbalance studies, iii) stabilizing ligand for magnetic nanoparticles-microbubbles conjugate via preliminary Langmuir monolayers studies.