Полиморфизм С-703Т-гена интерлейкина-5 и маркеры эозинофильного воспаления у больных бронхиальной астмой и их родственников

Markers of eosinophilic inflammation were studied in bronchial asthma patients and their relatives (bronchial hyperreactivity, eosinophils of nasal smear, total serum immunoglobulin E, interleukin-5). An association of C-703T interleukin-5 gene polymorphism and the disease was analysed. Results of our study showed a close relationship between eosinophils in nasal smear, total serum immunoglobulin E and bronchial hyperreactivity in mechanisms involved in asthma and atopy development. The statistically significant association of C-703T interleukin-5 gene polymorphism with asthma was shown.