Low prebiopsy state irritability scores at the clinical onset of invasive breast carcinoma

Abstract Objective The research findings regarding the role of psychiatric illness in breast cancer are not yet clear. This report investigates the differences between patients with invasive breast carcinoma (IBC) and patients with benign breast disease regarding the psychiatric history and the current prebiopsy psychopathology. Methods The psychiatric history of 124 females, aged 70 or less, was evaluated by interview and the DSM-IV criteria were used to establish the diagnoses. The Present State Examination (PSE)–Index of Definition (ID)–CATEGO computer program was used to define current psychopathology. Known risk factors of breast cancer were included in the analyses. Results After biopsy, 59 patients had IBC and 65 had benign breast diseases. Multiple logistic regression analyses showed that low psychiatric history and low irritability were independent predictors of IBC regarding the DSM-IV and the PSE–ID–CATEGO, respectively. Conclusion Low psychiatric history and low prebiopsy state irritability differentiates IBC patients from noncancer patients.