Whole‐brain atrophy assessed by proportional‐ versus registration‐based pipelines from 3T MRI in multiple sclerosis

Background and Purpose Whole‐brain atrophy is a standard outcome measure in multiple sclerosis (MS) clinical trials as assessed by various software tools. The effect of processing method on the validity of such data obtained from high‐resolution 3T MRI is not known. We compared two commonly used methods of quantifying whole‐brain atrophy.