1753 BRONCHOPULMONARY DYSPLASIA - WHO GETS IT? PERTINENT FACTORS

Many factors have been implicated in the development of BPD with 02 and IPPV being the most important. However, not all venilated infants develop BPD. In order to determine which factors associated with IPPV therapy contribute to the development of BPD, 145 successively ventilated infants were studied. All were in-born. The 75 infants who were ventilated for >3 days and survived >10 days were analyzed. Of these, 41 developed clinical ind radiological BPD and 33 did not. The two groups were similar (BPD vs non BPD) for GA (28.0 ± 3.0 vs 28.9 ± 3.4 weeks), BW (1167 ± 561 vs 1207 ± 534gms), sex, temperature on arrival at the NICU, appropriateness for GA, indication for ventilation, incidence of pneumothoraces (8/41 vs 6/33) and PDA (16/41 vs 14/33). Statistically significant differences were found in 02 exposure, peak pressures (28.6 ± 10 vs 21.5 ± 7.4 cm H2O, p = 0.001), length of time on pressure >20 cm H2O (13.0 ± 20.0 vs 3.6 ± 5 days p = 0.01) and duration of ventilation (27.7 ± 25.1 vs 10.8 ± 8 days p = 0.001). Our data support the concept that 02, pressures and time spent on IPPV are strongly associated with BPD. However, contrary to what has been previously reported, we found that the presence of pneumothoraces or PDA were not significant associated factors in the development of BPD.