Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Kenji Kawada,Akinori Arimura,Tatsuo Tsuri,Masahiro Fuji,Tadafumi Komurasaki,Shuji Yonezawa,Akira Kugimiya,Nobuhiro Haga,Susumu Mitsumori,Masanao Inagaki,Takuji Nakatani,Yoshinori Tamura,Shozo Takechi,Teruhiko Taishi,Junji Kishino,Mitsuaki Ohtani

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

1998

Kenji Kawada
Akinori Arimura
Tatsuo Tsuri
Masahiro Fuji
Tadafumi Komurasaki
Shuji Yonezawa
Akira Kugimiya
Nobuhiro Haga
Susumu Mitsumori
Masanao Inagaki
Takuji Nakatani
Yoshinori Tamura
Shozo Takechi
Teruhiko Taishi
Junji Kishino
Mitsuaki Ohtani

Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it possible to prepare 1 efficiently and in large quantity.

Keywords:

Regioselectivity
Aromaticity
Immunoglobulin E
Immunoglobulin E Antibody
Total synthesis
Organic chemistry
Chemistry

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