The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors

encodes a large transmembranemucin that is developmentally regulated and expressed alongtheundifferentiatedpseudostratifiedepithelium,asearlyas6.5weeks during fetal development. Immunohistochemical analy-sis of Muc4 expression in developing mouse lung and gastroin-testinal tract showed a different spatio-temporal pattern ofexpression before and after cytodifferentiation. The molecularmechanisms governing