Early Outcomes of 3D-printed Porous Titanium versus Polyetheretherketone (PEEK) Cage Implantation for Standalone Lateral Lumbar Interbody Fusion in the Treatment of Symptomatic Adjacent Segment Degeneration

Abstract Objective This study compared outcomes of 3D-printed porous titanium (Ti) versus polyetheretherketone (PEEK) cage implantation for standalone lateral lumbar interbody fusion (SA-LLIF) in the treatment of symptomatic adjacent segment degeneration (ASD). Methods 44 patients (59 levels) underwent SA-LLIF with Ti or PEEK cages between 10/2016 and 07/2020. The primary outcome was cage subsidence according to Marchi et al. Secondary outcomes included revision/recommendations for revision surgery, back/leg pain severity, changes in disc/foraminal height and global/segmental lumbar lordosis. Results 44 patients (21 female) were included with a mean age at surgery of 61.8±11.5 years, average radiological follow-up of 12.5±8.2 and clinical follow-up of 11.0±7.1 months. The overall subsidence rate was significantly less in the Ti versus PEEK group (20% vs. 58.8%; p=0.004). Revision was recommended to none of the patients in the Ti and 3 in the PEEK group (p=0.239). Furthermore, patients in the Ti group showed significantly better improvement in back pain NRS score (p=0.001). Disc height (p Conclusion In patients undergoing SA-LLIF for ASD treatment, 3D-printed Ti cages had significantly lower overall subsidence rate compared to PEEK cages. Furthermore, Ti cages resulted in fewer recommendations for revision surgery. Whether greater pain reduction in the Ti group is associated with earlier or higher fusion rates needs to be further elucidated.