Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106.

Sexual problems and dysfunction are common after therapy for breast and gynecologic malignancies.1-9 Commonly reported problems are difficulties with arousal and orgasm, decreased sexual desire and sexual satisfaction, and psychological effects related to an altered body image and partner factors.4-6,8 Jensen et al reported persistent sexual dysfunction and adverse vaginal changes after radiation for cervical cancer.10 Prevalence rates for sexual problems vary by cancer type and treatment modality, but often affect 50% or more of all female cancer patients.11-13 Despite the recognized prevalence of sexual problems in survivors, there are relatively few studies that address interventions for women who have sexual complaints following cancer therapy.14 One randomized, placebo-controlled study used a nutritional supplement, ArginMax, to treat sexual arousal disorder in healthy women without a history of cancer.15-16 After 4 weeks of therapy, the women who received the supplement reported significant improvement in sexual desire and satisfaction compared with those in the placebo arm. ArginMax consists of extracts of L-arginine, ginseng, ginkgo, and damiana as well as multivitamins and minerals. Nitrous oxide is a byproduct of L-arginine metabolism and results in nitric oxide production, which triggers signaling pathways that lead to vasodilatation. Arginine is believed to be required to carry out the synthesis of nitric oxide that relaxes blood vessels and allows more blood to flow through arteries. Improving hemodynamics and genital blood flow may improve sexual response in women, as well as orgasmic and clitoral sensations.17 Given the positive results of this study and the relative lack of medical therapies for female patients with sexual dysfunction, we designed a placebo-controlled clinical trial to evaluate the use of ArginMax in female cancer survivors. We hypothesized that treatment with the supplement would improve the overall sexual functioning of study participants.