176-LB: Ethnic Differences in Cardiovascular Complications of Young-Onset Diabetes (YOD)

Introduction: YOD (age at diagnosis [AAD] Methods: We included adults in Ontario, Canada with incident diabetes (2002-12, followed to 2018). We matched each case with ≤5 diabetes-free controls by age, sex, and ethnicity. The outcome was CVD (coronary artery disease, congestive heart failure, stroke, peripheral revascularization, lower extremity amputation). We constructed Cox proportional hazards models to estimate the association between AAD and CVD relative to controls. Results: We included 411,030 cases (3.5% South Asian; 4.3% Chinese) and 2,000,035 controls. The hazard ratios (HR) for CVD in UOD versus controls were higher in Chinese (2.38, 2.2-2.5) and South Asian (2.5, 2.4-2.7) people than White people (1.9, 1.9-1.9; pinteraction Discussion: Although Chinese and South Asian people have a lower hazard of CVD compared to White people, YOD is associated with a 4- to 5-fold greater hazard of CVD across ethnicities. Disclosure C. Ke: None. T. Stukel: None. A. Luk: Research Support; Self; Bayer Healthcare Pharmaceuticals Inc., Roche Pharma. Other Relationship; Self; Merck Sharp & Dohme Corp. J.C. Chan: None. B.R. Shah: None. Funding Canadian Institutes of Health Research; South Asian Network Supporting Awareness and Research