Blood lead concentrations and attention deficit hyperactivity disorder in Korean children: a hospital-based case control study

Background Because the developing brain of a child is vulnerable to environmental toxins, even very low concentration of neurotoxin can affect children’s neurodevelopment. Lead is a neurotoxic heavy metal which has the harmful effect on the striatal-frontal circuit of brain. This area of the brain is known to be closely related to attention deficit hyperactivity disorder (ADHD) pathophysiology. The primary objective of the present study was to investigate whether elevated blood lead concentration is a risk factor for ADHD. The secondary objective was to examine the association between blood lead concentration and symptom severity.