Novel hybrid natural products derived from solanesol as wound healing agents

A series of compounds 2a-g, 3a,b, 4a-n have been synthesized from solanesol 1, an acyclic terpenoid alcohol, extracted from tobacco waste. These compounds have been evaluated for antioxidant, angiogenesis and wound healing activity. Compounds 3b and 4h exhibit better wound healing activity in comparison to 3,3-dimethylacryl shikonin. These results indicate that Solanesol derivatives can be further developed as wound healing agents.