Frequency of relapse rates in rifampicin-resistant tuberculosis in operated patients

Background: Multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis (TB) are a complex problem in the world. Surgical treatment increases the chance of curing patients with MDR-TB or XDR. Study Concept: comparing of relapse rates in rifampicin-resistant cases for various periods after surgical chemotherapy. Methods: Retrospective study in CTRI from 2010 to 2011. 62 patients underwent surgical treatment of pulmonary tuberculosis. In all patients, tuberculosis was detected for the first time and MDR or XDR. After surgery, all patients received chemotherapy depending on the drug resistance. In 27 patients, the after surgery chemotherapy course was 6 months (group 1). In 35 patients, the course was 12 months (group 2). Compare frequency of relapse cases in group 1 and 2 patients. Results: In the 1st group there were 6 cases of cavernous pulmonary tuberculosis (22.8%), in the 2nd group - 24 (68.6%) (p1-2 0,1). Conclusions: reduction in chemotherapy after surgery for MDR and XDR-TB from 12 to 6 months does not lead to an increase in the frequency of postoperative relapse.