Copper-Mediated Synthesis of N-Alkenyl-α,β-unsaturated Nitrones and Their Conversion to Tri- and Tetrasubstituted Pyridines.
2015
A Chan-Lam reaction has been used to prepare N-alkenyl-α,β-unsaturated nitrones, which undergo a subsequent thermal rearrangement to the corresponding tri- and tetrasubstituted pyridines. The optimization and scope of these transformations is discussed. Initial mechanistic experiments suggest a reaction pathway involving oxygen transfer followed by cyclization.
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