Clinical and hematological significance of antigranulocyte autoantibodies

: Sera of thirty patients with acute and chronic immune neutropenias for different target cells: polymorphonuclear leukocytes (PMNL), macrophages, T and B lymphocytes are studied. An increase of the level of antigranulocyte antibodies is associated with a decrease of PMNL count, whereas a decrease of these antibodies' level is paralleled by an increase of the neutrophil count. It is noteworthy that the sera of patients with acute neutropenias contain autoantibodies similar to antibodies to CD13 antigen, which react mainly with the neutrophils. The sera of patients with chronic neutropenias contain antibodies similar to anti-CD45 antibodies and react with all target cells.