Effect of Bushen Qiangdu Recipe on Osteoporosis and Bone Loss of Patients with Ankylosing Spondylitis

Objective To observe the therapeutic effect of Bushen Qiangdu Recipe(BSQDR) on osteoporosis and bone loss in patients with ankylosing spondylitis(AS).Methods Patients with AS were randomally assigned to two groups.The 288 patients in the treatment group received BSQDR(consisting of cibotii rhizoma,antler,prepared rehmannia root,epimedium herb,rhizoma drynariae,teasel root,eucommia bark,pangolin scales,etc.,one dose daily,taken in two portions,once in the morning and once in the evening).The 72 patients in the control group received SIDSM and sulfasalazine.The therapeutic course for both was six months.Clinical symptoms,pillow distance from the wall,hand distance from the ground,jaw distance from the handle,chest mobility,Schober test,spinal mobility and other signs of disease activity indices(ESR and CRP) were observed in patients before and after treatment.The bone mineral density(BMD) testing was performed in the lumbar spine,the femur,the forearm,and the heels,etc.Osteocalcin(BGP),calcitonin,parathyroid hormone(PTH),etc.bone metabolic indices were detected.Results BASFI,BASDAI,the overall assessment,the spinal pain,pillow distance from the wall,hand distance from the ground,jaw distance from the handle,chest mobility,Schober test,spinal mobility,and so on were all improved to some extent when compared with before treatment in the treatment group(P0.05).The ESR and CRP decreased to various degrees,showing statistical significance when compared with before treatment(P0.01).BGP increased and PTH decreased,showing statistical difference when compared with before treatment(P0.05).The BMD in patients' lumbar spine,femoral neck,Ward's triangle,femoral trochanter increased to various degrees.The calcaneal intensity index,blood uric acid(BUA) and SOS values also increased more than before treatment,showing statistical significance(P0.05).Long-term oral administration of BSQDR was safe,with no obvious adverse reaction.Conclusions BSQDR showed significant effect in treatment of AS.It could regulate the bone metabolic level in patients,attenuate the immune inflammatory response,improve the spine and joint activities functions,increase bone formation,reduce bone resorption,thereby,enhancing the BMD,showing significant therapeutic effect on osteoporosis in AS patients.