[Effect of resveratrol on heart function of rats with adriamycin-induced heart failure].

Objective: To observe the protective effects of resveratrol(RES) on the heart function of the rats with adriamycin-induced heart failure.Method: Thirty adult male SD rats were randomly divided into 5 groups: normal control(NC) group,adriamycin(ADR) group, RESL+ADR group,RESH+ADR group and RES group.RES of 30,120,120 mg·kg-1·d-1 was given intraperitoneally(ip) once a day for 3 days in RESL+ADR group,RESH+ADR group and RES group respectively.The other two groups were given the same amount of normal saline the same way.On the 4th day,ADR of 10 mg·kg-1 was given intraperitoneally once to induce myocardium injury model.After twenty-four hours,the pathological and biochemical changes of the myocardium were examined.Result: As compared with NC group,the MDA,NO and NOS of the ADR group were significantly higher(P0.05),and the SOD of the ADR group were markedly lower(P0.05).As compared with ADR group,the indexes in RESL+ADR group,RESH+ADR group were exactly opposing,and took on dose dependance(P0.05).Light microscopic morphometry of the heart samples of the rats in ADR+RESL,H groups revealed typical diminishing of damage.Conclusion: RES can relieve the toxic effects of ADR on myocardium,and the cardioprotective effects may be correlated with its antioxidant activity and downregulation of NO.