One-pot Synthesis of Multifunctional Bi2S3 Nanoparticles and Construction of Core-shell Bi2S3@-Ce6-CeO2 Nanocomposites for NIR-Triggered Phototherapy

As a direct thin band gap n-type semiconductor, bismuth sulfide (Bi2S3) nanomaterial possesses great near-infrared (NIR) triggered photothermal effect, photoacoustic (PA) and computed tomography (CT) imaging property. Hence, Bi2S3 nanomaterial has become a research hotpot in multiple domains, such as the construction of NIR-triggered nanosystems for cancer therapy. In this paper, through simply one-pot synthesis with the assistance of EDTA-2Na, we first got monodisperse spherical Bi2S3 of uniform particle size with fascinating photothermal and PA/CT imaging property. Based on this, we introduced photosensitizer Ce6 with photodynamic property and CeO2 with the O2-evolving characteristic, thus designed a core-shell structure of Bi2S3@-Ce6-CeO2 nanocomposites (Bi2S3@-Ce6-CeO2 NCs). The as received Bi2S3@-Ce6-CeO2 NCs exhibited remarkable synergetic photothermal and photodynamic therapeutic effect both in vitro and vivo, demonstrating its promising potential for cancer treatments. In the long term, the multifunctional PA/CT properties of both Bi2S3 NPs and Bi2S3@-Ce6-CeO2 NCs in this study also supply a novel Bi2S3-basing platform for constructing integrated diagnosis and treatment platforms..