METABOLISM OF DIGOXIN: ROLE OF THE LIVER IN TRITIATED DIGOXIN DEGRADATION

The effect of circulatory bypass of the liver on the metabolism of tritiated digoxin was determined in seven dogs. Thin-layer chromatographic techniques were used in the separation of digoxin from its metabolites. Although the metabolism of digoxin was retarded following liver bypass, significant extrahepatic metabolism was observed under both control and bypass conditions.