Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population

Kiyoshi Migita,Minoru Nakamura,Seigo Abiru,Yuka Jiuchi,Shinya Nagaoka,Atsumasa Komori,Satoru Hashimoto,Shigemune Bekki,Kazumi Yamasaki,Tatsuji Komatsu,Masaaki Shimada,Hiroshi Kouno,Taizo Hijioka,Motoyuki Kohjima,Makoto Nakamuta,Michio Kato,Kaname Yoshizawa,Hajime Ohta,Yoko Nakamura,Eiichi Takezaki,Hideo Nishimura,Takeaki Sato,Keisuke Ario,Noboru Hirashima,Yukio Oohara,Atsushi Naganuma,Toyokichi Muro,Hironori Sakai,Eiji Mita,Kazuhiro Sugi,Haruhiro Yamashita,Fujio Makita,Hiroshi Yatsuhashi,Hiromi Ishibashi,Michio Yasunami

Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population

2013

Background/Aims Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study.

Keywords:

Genetic predisposition
Autoimmune hepatitis
Lupus erythematosus
Rheumatoid arthritis
STAT4
Cohort study
Genotype
Population
Medicine
Immunology
Cirrhosis
Allele

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