DIETARY RESTRICTION IN MICE BEGINNING AT 1 YEAR OF AGE: EFFECTS ON SERUM IMMUNE COMPLEX LEVELS

One year old mice from a long-lived strain were gradually subjected to life-prolonging dietary restriction. Serum immune complex and immunoglobulin G (abbreviated IgG) levels were measured at 13 and 23 months of age. Longitudinal and cross-sectional analyses showed reduced serum immune complex and IgG levels for mice underfed in adulthood.