Cardiac Tamponade after Ovarian Stimulation

To the Editor: The ovarian hyperstimulation syndrome is a potentially lethal complication of the administration of gonadotropin for the induction of ovulation. The condition occurs in up to 5% of patients undergoing in vitro fertilization.1 Typical manifestations include marked ovarian enlargement associated with shifts in extravascular fluid, leading to ascites and pleural and pericardial effusion. We report a case of cardiac tamponade in a 27-year-old woman after ovarian stimulation (administration of follicle-stimulating hormone at a daily dose of 75 IU for 15 days, gonadotropin-releasing hormone antagonist at a single dose of 3 mg, and human chorionic gonadotropin at a dose . . .