Drug-induced antibodies: interaction of the drug with a polymorphic platelet-antigen.

Preincubation of donor platelets with ticarcillin will prevent the reactivity of a platelet antibody against these platelets, whereas no influence was observed on antisera against HLA, 5A, 5b and Zwa. The implications for the mechanism of drug-induced antibodies with restricted specificity will be discussed. In part supported by the Dutch Organization for Health Research (TNO), the Dutch Foundation for Medical Research (FUNGO) which is subsidized by the Dutch Foundation for the Advancement of Pure Research (ZWO), the J. A. Cohen Institute for Radiopathology and Radiation Protection (IRS).