New peptides applications from the cytoplasmic domain of the amyloid precursor protein of

The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y1KQYTSIHHGY0 (SEQ ID NO:2), Y1KKQYTSIHHGY0 (SEQ ID NO:3) and Y1KKKQYTSIHHGY0 (SEQ ID NO:4), wherein Y0 is nil or represents V, VV, VVE, VVEV or VVVED and Y1 represents an internalisation and addressing peptide, derived from the 3 helix of homeodomains and structurally related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.