An Enantioselective Baylis-Hillman Reaction Catalyzed by Chiral Phosphines under Atmospheric Pressure.

Tadakatsu Hayase,Takanori Shibata,Kenso Soai,Yasuo Wakatsuki

An Enantioselective Baylis-Hillman Reaction Catalyzed by Chiral Phosphines under Atmospheric Pressure.

2010

Tadakatsu Hayase
Takanori Shibata
Kenso Soai
Yasuo Wakatsuki

2,2’-Bis(diphenylphosphino)-1,1’-binaphthyl (BINAP) catalyzes the enantioselective Baylis–Hillman reaction between pyrimidine- 5-carbaldehydes and acrylates to provide chiral α-methylene β-hydroxy esters in up to 44% ee under atmospheric pressure.

Keywords:

Atmospheric pressure
Baylis–Hillman reaction
Enantioselective synthesis
Chirality (chemistry)
Catalysis
Chemistry
Organic chemistry

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