Reducing ventilatory response to carbon dioxide by breathing cold air

To study the effect of cooling of nasal receptors on breathing we had 10 normal male volunteers rebreathe through their noses 8% CO2 in oxygen at “warm” (23 to 30° C) and at “cold” (−4 to 10° C) temperatures. In order to further examine the effect of nasal receptors on the control of breathing, 11 subjects had their nasal response to CO2 measured at the warm temperature before and after topical nasal anesthesia. To exclude an increase in nasal resistance as the cause of the reduced response to CO2, 10 subjects had their nasal resistance measured before and after nasal rebreathing of cold 8% CO2 in oxygen. To also exclude increased bronchial resistance, forced expiratory volume in one second (FEV1) was measured in 12 subjects before and after nasal breathing of cold oxygen for 3 min. The mean ventilatory response to CO2 was reduced from 3.0 ± 1.6 L/min/mmHg to 2.5 ± 1.1 L/min/mmHg (p < 0.05) by the cold air. Topical nasal anesthesia increased the response to CO2 at the warm temperature from 2.4 ± 0.7 to 2....