Effects of acute inhalation of fire extinguishing agent Novec 1230 on blood biochemical indexes in mice

Objective To investigate the effects of acute inhalation of fire extinguishing agent Novec 1230 on routine blood indexes and biochemical indexes in mice. Methods One hundred and twenty male ICR mice with an age range of 5 weeks and body mass of 18–22 g were randomly divided into the normal control group and the acute inhalation group, which were further divided into 3 subgroups, each consisting of 30 animals. The animals were exposed to the fire extinguishing agent Novec 1230 at concentration levels of 5%, 10% and 15% for 2 hours respectively, while the animals in the control group were exposed to common room air. Two time points(at 2 hours and 14 days after inhalation exposure)were set for each subgroups, which consisted of 15 mice. The routine blood levels and serum biochemical indexes of the mice were detected at the above 2 time points. Results Following exposure to the agent at levels of 5%, 10% and 15% for 2 hours, red blood cell (RBC) counts [(9.99±1.16)×1012, (9.90±0.68)×1012, (8.84±1.39)×1012/L] decreased gradually with the increase in exposure concentrations, and statistical significance could be noted, when they were compared with those of the control group [(9.16±1.18)1012/L] (P 0.05). Conclusions Acute exposure of fire extinguishing agent Novec 1230 seemed to induce infectious damage, myocardial and heptal damage to mice, however, the damage afflicted on the animals seemed to recover 14 days after exposure. Key words: Fire extinguishing agent novec 1230; Acute inhalation; Toxicity; Routine blood indexes; Blood biochemical indexes