Mechanistic insights into an unusual side chain mediated N-Cα bond cleavage under collision induced dissociation conditions in the disulfide containing peptide conopressin

Sanjeev Kumar,M. Achanna Venkatesha,Sahil Lall,Sunita Prakash,Padmanabhan Balaram

Mechanistic insights into an unusual side chain mediated N-Cα bond cleavage under collision induced dissociation conditions in the disulfide containing peptide conopressin

2020

Sanjeev Kumar
M. Achanna Venkatesha
Sahil Lall
Sunita Prakash
Padmanabhan Balaram

Conopressin, a nonapeptide disulfide CFIRNCPKG amide, present in cone snail venom undergoes a facile cleavage at the Cys(6)-Pro(7) peptide bond to yield a disulfide bridged b6 ion. Analysis of the ...

Keywords:

Collision-induced dissociation
Cone snail
Amide
Bond cleavage
Peptide bond
Stereochemistry
Side chain
Peptide
Analytical chemistry
Chemistry
Cleavage (embryo)

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