Synthesis and Biological Properties of New 1β-Methylcarbapenems Having Tetrazolothioether Moiety.
2000
Abstract The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
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