Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis

Abstract Objective To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue. Methods Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection. Results The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue ( P P P Conclusions The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis.