Lead compound and application thereof in preparation of drugs against castration-resistant prostate cancer
2016
Belonging to the technical field of biochemical pharmacy, the invention provides a lead compound and application thereof in preparation of drugs against castration-resistant prostate cancer (CRPC). The invention performs high-throughput virtual screening on FKBP51 and FKBP52 protein, and verifies the effectiveness of the obtained compounds on molecule, cellule and individual animal levels, explores the molecular mechanism by which a finally selected lead compound with development prospect acts on CRPC, and provides a new and more effective way for treatment of CRPC.
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