A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs

Xiaocui Zhu,Leah Santat,Mi Sook Chang,Jamie Liu,Joelle R. Zavzavadjian,Estelle A. Wall,Christine Kivork,Melvin I. Simon,Iain D. C. Fraser

A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs

2007

Xiaocui Zhu
Leah Santat
Mi Sook Chang
Jamie Liu
Joelle R. Zavzavadjian
Estelle A. Wall
Christine Kivork
Melvin I. Simon
Iain D. C. Fraser

Background Effective and stable knockdown of multiple gene targets by RNA interference is often necessary to overcome isoform redundancy, but it remains a technical challenge when working with intractable cell systems.

Keywords:

Gene knockdown
Genetics
Gene silencing
Gene targeting
Molecular biology
Small hairpin RNA
microRNA
RNA silencing
RNA interference
RNA polymerase II
Biology
Transcription (biology)

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