Treatment planning and delivery of shell dose distribution for precision irradiation
2010
The motivation for shell dose irradiation is to deliver a high therapeutic dose to the surrounding supplying blood-vessels
of a lesion. Our approach's main utility is in enabling laboratory experiments to test the much disputed hypothesis about
tumor vascular damage. That is, at high doses, tumor control is driven by damage to the tumor vascular supply and not
the damage to the tumor cells themselves. There is new evidence that bone marrow derived cells can reconstitute tumor
blood vessels in mice after irradiation. Shell dosimetry is also of interest to study the effect of radiation on neurogenic
stem cells that reside in small niche surface of the mouse ventricles, a generalized form of shell. The type of surface that
we are considering as a shell is a sphere which is created by intersection of cylinders. The results are then extended to
create the contours of different organ shapes. Specifically, we present a routine to identify the 3-D structure of a mouse
brain, project it into 2-D contours and convert the contours into trajectories that can be executed by our platform. We use
the Small Animal Radiation Research Platform (SARRP) to demonstrate the dose delivery procedure. The SARRP is a
portable system for precision irradiation with beam sizes down to 0.5 mm and optimally planned radiation with on-board
cone-beam CT guidance.
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