Vitamin D-induced coronary atherosclerosis in normolipemic swine: comparison with human disease.

Coronary atherosclerosis developed in normolipemic swine fed a basal ration supplemented with 125, 000 IU, 62, 500 IU and 31, 250 IU of vitamin D3/kg of diet for 3 months and subsequently only the basal ration for the following 3 months. Lesions consisted of intimal atheromata and calcified internal elastics and caused luminal narrowing. The incidence of atherosclerotic lesions was proportional to the vitamin D3 doses. The present experimentally induced lesions had many morphological features resembling those in coronary arteries from human subjects.