GENOMIC STRUCTURE OF THE HUMAN TATA-BOX-BINDING PROTEIN (TBP)

Abstract The gene encoding the human TATA-box-binding protein ( hTBP ) is contained within a 20-kb DNA fragment and is split into eight exons. The coding sequence is interrupted by six introns and the 5'-untranslated region ( 5′-UTR ) of the gene by a 2.5-kb intron. A comparison of the hTBP exon/intron organization with the various TBP cloned to date is presented.