Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Monica Dors,Anasuya Sarkar,Sarah E. Warren,Mark D. Wewers,Alan Aderem

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

2010

Edward A. Miao
Irina A. Leaf
Piper M. Treuting
Dat P. Mao
Monica Dors
Anasuya Sarkar
Sarah E. Warren
Mark D. Wewers
Alan Aderem

Pyroptosis is a form of proinflammatory cell suicide whose physiological importance is unclear. Aderem and colleagues show that pyroptosis can be integral to protection against bacterial infection.

Keywords:

Pyroptosis
Immunology
Cell biology
NLRC4
Intracellular parasite
Caspase-11
Caspase 1
Innate immune system
Biology
Proinflammatory cytokine
Effector

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