Evaluation of methods for modeling transcription factor sequence specificity

Matthew T. Weirauch,Atina G. Cote,Raquel Norel,Matti Annala,Yue Zhao,Todd Riley,Julio-Saez Rodriguez,Thomas Cokelaer,Anastasia Vedenko,Shaheynoor Talukder,Harmen J. Bussemaker,Quaid Morris,Martha L. Bulyk,Gustavo Stolovitzky,Timothy R. Hughes

Evaluation of methods for modeling transcription factor sequence specificity

2013

Matthew T. Weirauch
Atina G. Cote
Raquel Norel
Matti Annala
Yue Zhao
Todd Riley
Julio-Saez Rodriguez
Thomas Cokelaer
Anastasia Vedenko
Shaheynoor Talukder
Harmen J. Bussemaker
Quaid Morris
Martha L. Bulyk
Gustavo Stolovitzky
Timothy R. Hughes

The most comprehensive analysis to date of models of transcription-factor binding specificity reveals the best methods for predicting in vivo binding from in vitro data.

Keywords:

DNA-binding protein
Transcription factor
Functional genomics
In vivo
Protein Array Analysis
Position-Specific Scoring Matrices
Molecular biology
Genome
Binding selectivity
Biology
Genetics

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