Preparation and use of bifenil-4-ilcarbonylamino acid derivatives for the treatment of obesity.

A compound of formula (I) ** Formula ** in which Q is O, NR11, or S; it is a condensed ring selected from an aromatic 6-membered ring containing 0 or 1 N atoms; R1 is independently selected from halogen, (C1-C6) alkyl, (C1-C6) alkoxy, nitro, cyano, halo (C1-C6) alkyl, halo (C1-C6) haloalkoxy, aminocarbonyl, ((C1-C6) alkyl) aminocarbonyl , bis [(C1-C6) alkyl] aminocarbonyl, aminosulfonyl, ((C1-C6) alkyl) aminosulfonyl, bis [C1-C6 alkyl]] aminosulfonyl, ((C1-C6) alkyl) carbonylamino, (C1- alkyl C6)) sulfonyl, ((C1-C6) alkyl) sulfonylamino, hydroxy ((C1-C6) alkyl) aminocarbonyl, 1-morpholinylcarbonyl, and 1- piperidinylcarbonyl, and when two of said R1 substituents are (C1-C6) alkyl and they are attached to adjacent carbon atoms of ring A, they can be joined to form a 5-7 membered carbocyclic ring; n is 0, 1 or 2; R2 and R3 are independently selected from hydrogen, halogen, hydroxy, (C1-C6) alkyl, trifluoromethyl, (C1-C6) alkoxy, and trifluoromethoxy; R4 is selected from ** Formula ** in which R6 is H or CH3; and R7 is ** Formula ** in which R9 is selected from (C1-C6) alkyl optionally substituted with one or two groups selected from vinyl, CF3, OH, methoxy, SCH3, NH2, -CO2H, and -CONH2, ( CH2) mphenyl, in which m is 0 to 3, and in which the phenyl ring is optionally substituted with one or two groups selected from halogen, (C1-C6) alkyl, (C1-C6) alkoxy, OH, nitro, and cyano, piperidinyl optionally substituted in C with halogen, and optionally substituted in C or N with (C1-C6) alkyl, (C1-C6) alkoxy, nitro, or cyano, tetrahydropyran-4-yl; R10 is H or methyl; or R9 and R10 may form, together with the carbon to which they are attached, a 3- to 6-membered carbocyclic ring, R8 is hydrogen, (C1-C4) alkyl, hydroxy, or methoxy; R5 is selected from H, (C1-C6) alkyl, and hydroxy ((C2-C6) alkyl); R11 is selected from H, (C1-C6) alkyl, and hydroxy ((C2-C6) alkyl); and its pharmaceutically acceptable esters and salts.