Production of curie quantities of 68Ga with a medical cyclotron via the 68Zn(p,n)68Ga reaction

Abstract PET imaging with 68 Ga-labeled tracers has seen a dramatic increase over the past five years primarily due to the increased accessibility of 68 Ge/ 68 Ga generators, the availability of tracers with superb targeting properties for labeling, straightforward labeling procedures and the approval of these tracers by regulatory entities. Available 68 Ge/ 68 Ga generators nominally deliver up to 1.85 GBq (50 mCi) when fresh limiting production and distribution of 68 Ga-labeled tracers to a few daily doses per generator. The focus of this study was to provide a simple and efficient method for 68 Ga production in clinically relevant quantities using a low energy medical cyclotron with a solid target.