1,5 Anhydroglucitol Evaluation as Glycemic Control Parameter of Diabetes Mellitus in Pregnancy

Summary D iabetes mellitus is an important medical problem during pregnancy, causing perinatal morbidity, mortality, spontaneous abortion, stillbirth and congenital malformations despite improved outcome reflected by a steep decline in perinatal mortality over the past few decades, controversy still exists regarding the care of the pregnant woman with both pre-existing and gestational Diabetes Mellitus and method of treatment. The importance of an appropriate and stable long-term mean glycemic control commonly measured by the HbA1c, for the incidence of diabetic complications has been widely showed its importance. The HbA1c reflects the glycemic metabolism of the past 2-3 months and can therefore be recognized as long-term glycemic marker. In contrast, it is only slightly influenced by short-term glycemic excursions, e.g. states of postprandial hyperglycemia, the measurement of 1,5-Anhydroglucitol (1,5-AG) provides a reliable opportunity to assess the frequency and extent of intermittent hyperglycemic episodes.