Изучение фармакокинетики [3Н]-циклопролилглицина в крови крыс
2018
Resume. The objective of this study is to evaluate pharmacokinetic parameters of tritium-labeled cycloprolylglycine [ 3 H] -CPG following intravenous bolus administration of 5.7 μg (2 mCi). [ 3 H] -CPG was prepared by solid-state catalytic isotopic exchange with spillover-tritium. It was found that plasma concentration-time profile of [ 3 H] -CPG is adequately fit by a two-compartment model. The pharmacokinetic parameter estimates revealed rapid а-phase (distribution phase) (T 1/2α min) followed by a slower β-phase of elimination (T 1/2β 80 min). These findings are consistent with previous results of pharmacokinetic study of CPG as a noopept metabolite. CPG is differ significantly from other therapeutic peptides in pharmacokinetic profile (T 1/2 , MRT, etc), which implies that CPG has a more prolonged duration of action.
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