Stimulation of AT2 Receptor Decreases Collagen Expression and Inhibits Myofibroblast Differentiation to Protect Against Bleomycin-induced Pulmonary Fibrosis

Ashok Kumar,Anandharajan Rathinasabapathy,Alana Horowitz,Kelsey Horton,Diana Martinez,Mohan K. Raizada,Ulrike Muscha Steckelings,Thomas Unger,Colin Sumners,Vinayak Shenoy,Michael J. Katovich

Stimulation of AT2 Receptor Decreases Collagen Expression and Inhibits Myofibroblast Differentiation to Protect Against Bleomycin-induced Pulmonary Fibrosis

2016

Ashok Kumar
Anandharajan Rathinasabapathy
Alana Horowitz
Kelsey Horton
Diana Martinez
Mohan K. Raizada
Ulrike Muscha Steckelings
Thomas Unger
Colin Sumners
Vinayak Shenoy
Michael J. Katovich

We have observed that activation of the AT2 receptor by a non-peptide agonist, Compound 21 (C21), protects against Bleomycin (Bleo)-induced Pulmonary Fibrosis (PF) in rats. This study was designed ...

Keywords:

Pulmonary fibrosis
Diabetes mellitus
Bleomycin
Myofibroblast
Internal medicine
Biology
Endocrinology
Agonist
Pharmacology
Receptor
Stimulation

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