Advances in chromatography coupled to mass spectrometry-related techniques for analysis of endocrine disruptors in food.

Abstract Analytical methods dedicated to endocrine-disrupting chemicals (EDCs) in food require high performances both in terms of sample preparation and measurement. Focused on confirmatory methods based on chromatography coupled to mass spectrometry (MS), this chapter presents the current state-of-the art in the field from real cases studies dealing with various classes of estrogenic EDCs. It also illustrates potential benefits associated to the more recent innovations of these MS-coupled techniques including ultra-resolutive systems in liquid (fast-LC, UPLC™) and gas chromatography (two-dimensional GC × GC), new types of ionisation techniques (photoionisation) and mass analysers (linear ion trap, Orbitrap™), or emerging technologies (bioassay-MS coupling, metabolomics).