Time course of reendothelialization with Polyzene-F nanocoated Cobra PzF ™ coronary stent on rabbit iliac arteries

Abstract Purpose Evaluation of reendothelialization with a new thin struts cobalt chromium alloy stent coated with a nano-layer of Polyzene™-F (PzF) in a rabbit iliac artery model. Methods Fifteen stented external rabbit iliac arteries were harvested at Day 7 for electron microscopy analysis following Cobra PzF stents implantation to assess reendothelialization and compare to historical data. Ten additional rabbits were used to assess time course of reendothelialization at 3 and 5 days. Results At Day 7, almost complete coverage of endothelial cells was observed with a coverage of 99.54 +/− 0.25% of the stented area. No thrombus area was noted. At Day 3, more than half of examined pieces was reendothelialized and reached 78.30 +/− 3.7% at Day 5 (p  Conclusions Reendothelialization was rapid and complete at Day 7. This is the fastest reendothelization process after stenting in this model. No stent occlusion was observed. Abbreviations and acronyms PzF Poly-bis(trifluoroethoxy) phosphazene DAPT Dual antiplatelet therapy BMS Bare metal stent DES Drug eluting stents Cobra PzF™ cobalt chromium alloy stent designed coated with a nano-layer of Polyzene™-F