Induction of Mammary Tumors in Rats by Single-Dose Gamma Irradiation at Different Ages

The effect of age at exposure on induction of mammary tumors was studied in female rats of the inbred WAG/Rij strain. Groups of 40 animals were exposed to a single total-body dose of 1 or 2 Gy of137 Cs γ radiation at ages of 8, 12, 16, 22, 36 or 64 weeks and were observed for life. Mammary tumors, identified as nodules persisting and growing for 6 weeks, were resected and classified histologically as carcinoma or fibroadenoma. The age-specific incidence of mammary carcinoma was compared with that in a group of 120 unirradiated control rats, using lifetime statistical analysis with both parametric and nonparametric methods. The excess normalized risk of carcinoma was 0.9 for 1 Gy and 2.2 for 2 Gy in age groups 8-36 weeks, with no significant differences between the age groups. However, irradiation at 64 weeks yielded fewer carcinomas than in the controls, the excess normalized risk being -0.7 and -0.3 for 1 and 2 Gy, respectively. The occurrence of one or more fibroadenomas did not influence the incidence ...